2024-至今 中国科学院上海有机化学研究所，助理研究员
2022-2024 中国科学院上海有机化学研究所，博士后
2017-2022 复旦大学，博士
2013-2017 华东理工大学，学士
2024-present Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Assistant Research Fellow
2022-2024 Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Postdoc
2017-2022 Fudan University, Ph.D.
2013-2017 East China University of Science and Technology, B.S.
质谱（Mass Spectrometry. MS）技术可以高效分析和表征目标物的组成、结构及质量信息。该技术凭借分析灵敏、检测快速、操作简单等特性，已被广泛应用于未知化合物的鉴定、反应中间体的捕获、反应筛选、及分子特异性识别等相关领域。为进一步开发质谱技术，我们的研究方向主要集中于：
（1）开发“软”电离质谱技术
目前已有的质谱技术对弱稳定化合物的电离存在易产生碎片，无法得到完整结构信息的问题，长期困扰着超分子化学领域分子表征。我们将开发更“软”的质谱离子化技术，在保证检测灵敏度的同时，实现弱稳定化合物的完整表征。
（2）自主研制制备级质谱仪器
常规商业化质谱功能单一，难以满足对多种复杂化学反应过程监测和中间体的表征。我们将自主研制多功能制备级质谱，适用于活性中间体的精准捕获和高通量沉积制备，并且可与扫描隧道显微镜(STM)等其他表征手段联用，实现化合物的多维度全面表征。
（3）新型质谱表征技术应用研究
基于质谱可精确测量化合物的质荷比并在复杂体系中辨识目标化合物，我们将致力于捕获活性中间体以明晰反应机理，高通量筛选平台的搭建，以及在线原位质谱衍生化和质谱成像技术的开发。推动合成化学、超分子化学，生物医药等领域的科研进展和技术创新。
Mass spectrometry (MS) technique can effectively analyze and characterize the composition, structure, and mass information of target substances. Owing to its high analytical sensitivity, rapid detection capabilities, MS technique has been widely applied in various research fields, including the identification of unknown compounds, the capture of reactive intermediates, the monitoring of reaction processes, and the specific recognition of molecules. In order to further the development of mass spectrometry technologies, our research focuses on:
(1) Development of "soft" ionization mass spectrometry techniques
Labile compounds tend to fragment during MS analysis, failing to obtain complete structural information, which is a persistent challenge in the field of supramolecular chemistry. We aim to develop softer ionization techniques that maintain high detection sensitivity and facilitate the comprehensive characterization of labile compounds.
(2) The development of preparative mass spectrometry instruments
Traditional commercial mass spectrometers are typically limited to providing basic mass-to-charge ratio (m/z) information and are insufficient for monitoring diverse and complex chemical reactions. We propose to develop multifunctional preparative mass spectrometry systems that are adept at the precise capture of active intermediates and capable of high-throughput deposition. These systems would be integrated with other advanced characterization technologies such as scanning tunneling microscopy (STM) to enable a multidimensional characterization of compounds.
(3) The applications of mass spectrometry characterization techniques
Given the precise measurement and identification of complex compounds by mass spectrometry techniques, we will focus to capture active intermediates to elucidate reaction mechanisms, establish high-throughput reaction screening platforms, and develop online chemical derivatization and mass spectrometry imaging technologies. These will contribute to propel scientific and technological advancements in synthetic chemistry, supramolecular chemistry, and biopharmaceuticals.
1. Liu, Y.; Bai, J.; Dong. X.; Cao, Y.; Bao, M.; Lu, Y.; Zeng, H.; Zhan, L.;* Guo, Y.* Online Charge-Generation Derivatization by Electrochemical Radical Cations of Thianthrene: Mass Spectrometry Imaging of Estrogens in Biological Tissues. Anal. Chem. 2024, 96, 12473?12481.
2. Liu, Y.;Huang, Y.; Wu, M.; Kong, S.; Cao, W.; Li, S.; Yan, G.; Liu, B.; Yang, P.; Zhang, Q.;* Qiao, L.;* Shen, H.* Microfluidic free-flow paper electrochromatography for continuous separation of glycans. ChemElectroChem, 2022, e202200106.