围绕合成化学中的需求为导向，我们搭建制备质谱（pMS），实现合成大分子的在线分析、分离和表征。工作重点从理论模拟入手，加快仪器研制的可靠性，充分发挥制备质谱的优势，推动有机合成机制及组装规律研究。
（1）开发阵列式感应电喷雾源电离大分子，采用非接触感应脉冲电离源，保证高效电离的同时，较高的离子流通量，提升制备质谱的效率。
（2）研发新型的多级离子传输和质谱，实现大束流离子的选控和m/z分析，实现有机合成分子的沉积和高纯制备，有效地避免溶剂和空气分子对样品的污染。
（3）设计特种真空手提箱进行沉积样品的转移，与商品化的STM仪器进样系统匹配，实现化合物的原子级分辨率与STM成像表征。
Focusing on the demands of synthetic chemistry, we develop preparative mass spectrometry (pMS) for the online analysis, separation, and characterization of synthetic macromolecules. The primary focus of the work begins with theoretical simulations to enhance the reliability of instrument development, leveraging the advantages of preparative mass spectrometry to advance research on organic synthesis mechanisms and assembly principles.
(1) Development of Array-based Inductive Electrospray Ionization for Macromolecules: By utilizing a pulsed electric field-induced electrospray, this ensures efficient ionization while maintaining a high ion flux, significantly improving the efficiency of preparative mass spectrometry.
(2) Research and Development of New Multi-stage Ion Transport and Mass Spectrometry: This enables the control and analysis of large ion beams and m/z ratios, allowing for the deposition and high-purity preparation of organic synthetic molecules while effectively preventing contamination from solvents and air molecules.
(3) Design of a Special Vacuum Portable Box for Sample Transfer: This facilitates the transfer of deposited samples to be compatible with commercial Scanning Tunneling Microscope (STM) instrument injection systems, ultimately achieving atomic-level resolution and STM imaging characterization of compounds.
1. Xu, T.#.; Li, H.#; Dou, P.; Luo, Y.; Pu, S.; Mu, H.; Zhang, Z.; Feng, D.; Hu, X.; Wang, T.; Tan, G.; Chen, C.; Li, H.; Shi, X.; Hu, C.; Xu, G. Concentric Hybrid Nanoelectrospray Ionization-Atmospheric Pressure Chemical Ionization Source for High-Coverage Mass Spectrometry Analysis of Single-Cell Metabolomics. Advanced Science 2024, e2306659. (#: equal contribution to the work).
2. Zhang, Z.; Cang, H.; Wei H, Y.; Li, H.*; Li, H.* Photoionization Ion Mobility Analyzer for On-site Measurement of Exhaled Acetone by Coupling Miniature Thermoelectric Cooling Dehydration. Sensors and Actuators B: Chemical 2024
3. Zhang, Z.; Cang, H.; Xie, Y.; Li, H.*; Li, H.* A miniaturized photodiode-based chemiluminescence sensor for measurement of fractional exhaled nitric oxide. Sensors and Actuators B: Chemical 2023, DOI: 10.1016/j.snb.2023.134402
4. Wang, W.#.; Li, H.#; Huang, W.; Chen, C.; Xu, C..; Ruan, H.; Li, B.; Li, H. Recent development and trends in the detection of peroxide-based explosives Talanta 2023, 264, 124763. (#: equal contribution to the work)
5. Meng, S. #; Li, Q. #; Zhou, Z. #; Li, H. #; Liu, X.; Pan, S.; Li, M.; Wang, L.; Guo, Y.; Qiu, M.; Wang, J. JAMA Netw Open 2021, 4, e213486. (#: equal contribution to the work)
6. Li, H.*; Liu, W.; Kan, R. A compact low-noise photodiode detection system for chemiluminescence nitric oxide analyzer. Rev. Sci. Instrum. 2019, 90, 046103.